Table 2 Escape latency data of compounds 8, 9, 10, 15, 16, 17, 18, 19 and 23.
Compound | μM of AChE/min/mg protein | LPO assay, MDA levels (nM/mg of tissue) | Nitrite assay, nitrite conc. (μM/mg) protein | GSH assay, μmol of GSH/mg Protein | SOD assay, SOD units/mg protein | Catalase assay, Catalase activity min−1 |
|---|---|---|---|---|---|---|
Control | 0.03 ± 0.01 | 16.78 ± 0.04 | 17.88 ± 0.06 | 0.28 ± 0.001 | 4.6 ± 0.03 | 11.61 ± 0.07 |
Scopolamine | 0.05 ± 0.056 | 25.09 ± 0.03 | 31.21 ± 0.06 | 0.08 ± 0.002 | 0.78 ± 0.01 | 2.25 ± 0.031 |
Donepezil | 0.02 ± 0.01 | 16.76 ± 0.04 | 16.63 ± 0.06 | 0.18 ± 0.001 | 3.0 ± 0.03 | 10.3 ± 0.09 |
8 | 0.01 ± 0.01 | 9.71 ± 0.03 | 11.92 ± 0.05 | 0.11 ± 0.001 | 4.07 ± 0.03 | 5.23 ± 0.02 |
9 | 0.01 ± 0.01 | 8.48 ± 0.02 | 10.42 ± 0.04 | 0.11 ± 0.002 | 4.09 ± 0.02 | 6.23 ± 0.02 |
10 | 0.01 ± 0.01 | 8.52 ± 0.05 | 12.82 ± 0.04 | 0.10 ± 0.005 | 3.07 ± 0.04 | 4.3 ± 0.01 |
15 | 0.02 ± 0.02 | 8.54 ± 0.02 | 14.66 ± 0.04 | 0.09 ± 0.003 | 3.14 ± 0.03 | 5.35 ± 0.03 |
16 | 0.01 ± 0.01 | 8.52 ± 0.05 | 11.74 ± 0.03 | 0.11 ± 0.002 | 3.07 ± 0.02 | 4.66 ± 0.04 |
17 | 0.02 ± 0.01 | 8.73 ± 0.05 | 12.57 ± 0.05 | 0.11 ± 0.006 | 3.09 ± 0.02 | 4.76 ± 0.02 |
18 | 0.01 ± 0.01 | 8.52 ± 0.02 | 10.51 ± 0.03 | 0.11 ± 0.001 | 4.08 ± 0.02 | 5.53 ± 0.01 |
19 | 0.01 ± 0.02 | 9.25 ± 0.02 | 11.31 ± 0.03 | 0.09 ± 0.005 | 3.09 ± 0.03 | 5.17 ± 0.05 |
23 | 0.01 ± 0.04 | 9.77 ± 0.04 | 15.2 ± 0.03 | 0.10 ± 0.007 | 3.07 ± 0.02 | 5.13 ± 0.03 |
