Table 3 Statistical values of different parameters of the built atom-based 3D-QSAR model.

From: Investigation, scaffold hopping of novel donepezil-based compounds as anti-Alzhiemer’s agents: synthesis, in-silico and pharmacological evaluations

# Factors

SD

R2

R2 CV

R2 Scramble

Stability

F

P

RMSE

Q2

Pearson-r

1

0.6837

0.5597

0.0736

0.6128

0.718

58.5

9.84E−10

0.54

0.6251

0.8323

2

0.3542

0.8844

0.2262

0.844

0.44

172.2

8.24E−22

0.44

0.7507

0.8752

3

0.1966

0.9652

0.3027

0.925

0.393

406.4

4.43E−32

0.49

0.6808

0.8252

4

0.1183

0.9877

0.2879

0.959

0.322

861.1

2.01E−40

0.41

0.7762

0.8918

5

0.0965

0.992

0.3058

0.9714

0.33

1040.2

7.40E−43

0.42

0.7675

0.8888

  1. QSAR quantitative structure–activity relationship, RMSE root mean square error, SD standard deviation.
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