Table 2 Multivariable analysis of non-relapse mortality and overall mortality for daily urinary Na/K ratio.

From: Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults

 

Non-relapse mortality

Overall mortality

 

HR (95% CI)

P-value

HR (95% CI)

P-value

Landmark at 14 days

 Low daily urinary Na/K ratio at 14 days

4.82 (1.81–12.83)

0.001

1.59 (0.82–3.07)

0.163

 Age ≥ 45 years

4.71 (1.22–18.16)

0.024

1.64 (0.85–3.17)

0.135

 HCT-CI ≥ 3

1.10 (0.36–3.33)

0.859

0.84 (0.39–1.80)

0.666

 High-risk disease status at CBT

1.51 (0.54–4.20)

0.427

2.33 (1.25–4.34)

0.007

 Cord blood TNC ≥ 2.5 × 107/kg

0.89 (0.35–2.23)

0.803

0.70 (0.39–1.24)

0.225

 HLA disparities ≥ 3

1.49 (0.58–3.83)

0.399

1.06 (0.60–1.87)

0.826

 Female donor to male recipient

4.12 (1.54–10.97)

0.004

2.20 (1.23–3.96)

0.007

 TBI 2–4 Gy-based regimens

3.21 (1.05–9.80)

0.004

1.39 (0.68–2.83)

0.361

Landmark at 28 days

 Low daily urinary Na/K ratio at 14 days

4.47 (1.32–15.12)

0.015

2.38 (1.15–4.91)

0.018

 Age ≥ 45 years

9.03 (1.84–44.38)

0.006

2.16 (1.07–4.36)

0.030

 HCT-CI ≥ 3

1.57 (0.49–4.97)

0.441

0.91 (0.42–1.96)

0.819

 High-risk disease status at CBT

1.00 (0.36–2.76)

0.986

1.91 (1.03–3.55)

0.038

 Cord blood TNC ≥ 2.5 × 107/kg

0.95 (0.35–2.54)

0.927

0.69 (0.39–1.24)

0.219

 HLA disparities ≥ 3

1.88 (0.68–5.21)

0.220

1.09 (0.61–1.94)

0.767

 Female donor to male recipient

2.47 (0.90–6.81)

0.078

1.94 (1.08–3.50)

0.026

 TBI 2–4 Gy-based regimens

2.46 (0.77–7.80)

0.124

1.18 (0.56–2.48)

0.654

  1. Na/K sodium-to-potassium, HCT-CI hematopoietic cell transplantation specific comorbidity index, CBT cord blood transplantation, TNC total nucleated cell, HLA human leukocyte antigen, TBI total body irradiation.
  2. The P-values in bold are statistically significant (< 0.05).