Table 3 Clinical parameters, complications, and administrated drugs based on daily urinary Na/K ratio.

From: Low urinary sodium-to-potassium ratio in the early phase following single-unit cord blood transplantation is a predictive factor for poor non-relapse mortality in adults

 

Urinary Na/K ratio at 14 days

  

Urinary Na/K ratio at 28 days *

  
 

Low

High

P-value

Low

High

P-value

Number of evaluable patients

46

126

 

27

142

 

Parameters

 Urine volume, (IQR) ml/day

2898 (2611–3324)

3290 (2874–3845)

0.003

3010 (2315–3190)

3153 (2600–3639)

0.086

 Rate of weight gain, (IQR) %

2.9 (0.6 to 4.8)

1.2 (− 1.1 to 2.8)

0.001

2.6 (− 1.7 to 5.8)

0.7 (− 1.5 to 3.0)

0.126

 Creatinine clearance, (IQR) ml/min

105.7 (77.3–143.0)

122.1 (90.9–151.4)

0.128

115.4 (68.8–133.4)

102.0 (74.8–131.8)

0.792

 FENa, (IQR) %

0.36 (0.21–0.49)

0.61 (0.45–0.82)

 < 0.001

0.35 (0.24–0.58)

0.75 (0.58–1.04)

< 0.001

 Serum albumin, (IQR) g/dL

2.9 (2.7–3.2)

3.1 (2.8–3.3)

0.102

3.3 (3.0–3.5)

3.2 (2.9–3.4)

0.424

 Serum Na, (IQR) mEq/L

130.5 (126.0–134.0)

132.0 (129.0–135.0)

0.039

131.0 (127.0–133.5)

135.0 (132.0–137.0)

0.001

 Serum K, (IQR) mEq/L

3.75 (3.50–4.10)

4.20 (3.80–4.50)

 < 0.001

3.90 (3.65–4.25)

4.10 (3.80–4.50)

0.061

 Serum CRP, (IQR) mg/dL

5.36 (2.36–9.35)

3.56 (1.53–6.85)

0.024

0.26 (0.14–1.27)

0.50 (0.22–1.43)

0.201

Complications

 Bacteremia

4 (8.7%)/46

18 (14.3%)/126

0.443

3 (11.1%)/27

19 (13.4%)/142

1.000

 PES

20 (57.1%)/35

44 (41.9%)/105

0.123

19 (86.4%)/22

84 (73.0%)/125

0.281

 High-grade fever (≥ 38.3 °C )

32 (69.6%)/46

60 (47.6%)/126

0.015

6 (22.2%)/27

24 (16.9%)/142

0.582

 Grade II–IV aGVHD

14 (31.1%)/45

21 (17.5%)/120

0.085

14 (51.9%)/27

71 (52.2%)/136

1.000

 Grade III–IV aGVHD

1 (2.3%)/44

2 (1.7%)/119

1.000

4 (14.8%)/27

4 (3.0%)/134

0.028

Administered drugs

 Diuretics

8 (17.4%)/46

22 (17.5%)/126

1.000

5 (18.5%)/27

42 (29.6%)/142

0.349

 Low-dose dopamine

27 (58.7%)/46

47 (37.3%)/126

0.015

16 (59.3%)/27

80 (56.3%)/142

0.835

 Corticosteroid 1–2 mg/kg/day

4 (8.7%)/46

5 (4.0%)/126

0.251

4 (14.8%)/27

9 (6.3%)/142

0.227

 Corticosteroid 2 mg/kg/day

2 (4.3%)/46

2 (1.6%)/126

0.290

4 (14.8%)/27**

5 (3.5%)/142**

0.037

  1. IQR interquartile range, FENa fractional excretion of sodium, CRP C-reactive protein, PES pre-engraftment syndrome, aGVHD acute graft-versus-host disease, Na/K sodium-to-potassium.
  2. The P values in bold are statistically significant (< 0.05).
  3. *Three patients died or developed anuria before the evaluation of daily urinary Na and K excretion at day 28.
  4. **Among 9 evaluable patients who received a higher dosage of corticosteroids (2 mg/kg/day) by 28 days, 7 patients experienced grade III–IV acute GVHD by 28 days.
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