Figure 2

(a) Representative immunoprecipitation-Western blot analysis for RyR1 with oxidized thiol groups and their matched total content in homogenate (upper panels) and interaction between RyR1 and calstabin1 (lower panels). BL—baseline; 6 M—6 month follow up. (b,c) Quantification of relative oxidized RyR1 and the RyR-calstabin1. Results are expressed as mean with SEM. Wilcoxon signed-rank test.