Table 4 The results for precision of the proposed methods.
Method for determination of drug | Ratio of drug in mixture (MEL:BUP) | Concentration taken (μg mL−1) | Intra-day precision | Inter-day precision | ||
|---|---|---|---|---|---|---|
Mean concentration found* (μg mL−1) | % RSD | Mean concentration found* (μg mL−1) | % RSD | |||
Direct spectrophotometry for determination of (MEL) | 25:750 | 25 | 25.31 | 0.47 | 25.37 | 0.55 |
60:300 | 60 | 60.97 | 0.09 | 60.51 | 0.66 | |
100:100 | 100 | 99.2 | 1.16 | 100.92 | 1.51 | |
DWD for determination of (BUP) | 25:750 | 750 | 735.93 | 0.1 | 742.6 | 0.79 |
60:300 | 300 | 297.57 | 0.23 | 298.48 | 0.94 | |
100:100 | 100 | 99.3 | 0.53 | 99.63 | 0.67 | |
MCR-ALS for determination of (MEL) | 50:200 | 50 | 50.3 | 0.66 | 50.4 | 0.86 |
40:300 | 40 | 40.19 | 0.98 | 40.9 | 0.98 | |
80:500 | 80 | 80.6 | 0.56 | 81.6 | 0.56 | |
MCR-ALS for determination of (BUP) | 50:200 | 200 | 203.5 | 1.82 | 200.9 | 1.82 |
40:300 | 300 | 295.76 | 1.56 | 305.1 | 1.56 | |
80:500 | 500 | 501.66 | 1.03 | 504.66 | 1.03 | |
