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Figure 1

From: Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt–Jakob disease

Figure 1

Automatic segmentation of diffusion restriction lesions (DRL) in the supratentorial brain area of the diffusion-weighted image (DWI, b = 1000). (a) Affine transformation to the DWI (b = 1000) template (see Supplemental Fig. e-1). (b) Inverse transformation of the regional masks (gray matter (GM), Deep GM, and white matter (WM)) to the original DWI space. (c) Voxel intensities of the DWI were normalized using the mean signal intensity of the inversely transformed WM mask area. (d) Diffusion restriction lesion masks were automatically segmented using the thresholding method (see the “Materials and methods” section) in both GM and deep GM regions.

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