Table 1 Demographic characteristics of the participants.

From: Nonlinear relationship between gonadotropin total dose applied and live birth rates in non-PCOS patients: a retrospective cohort study

Demographic characteristics

FSH total dose applied (IU)

P value

Tertile1: < 2170

Tertile2: 2171–2849

Tertile3: > 2850

N

3828

3924

3893

 

Female age (years)

29.8 ± 4.7

30.7 ± 4.6

31.8 ± 4.8

 < 0.001

Male age (years)

30.7 ± 5.2

31.5 ± 5.0

32.4 ± 5.3

 < 0.001

Infertility duration (years)

3.0 (2.0–5.0)

3.0 (2.0–5.0)

3.0 (2.0–5.0)

 < 0.001

BMI (kg/m2)

22.6 ± 3.2

23.2 ± 3.4

24.0 ± 3.8

 < 0.001

Basal FSH (mIU/ml)

7.6 ± 3.3

7.9 ± 3.8

8.3 ± 3.7

 < 0.001

Basal E2 (pg/ml)

32.0 (16.7–49.0)

31.8 (15.9–48.0)

30.0 (15.0–47.0)

 < 0.001

Basal P (ng/ml)

0.6 (0.4–0.9)

0.6 (0.4–0.9)

0.6 (0.3–0.9)

0.337

Basal LH (mIU/ml)

4.3 (3.1–5.8)

4.1 (3.0–5.5)

4.0 (3.0–5.5)

 < 0.001

AFC

12.8 ± 5.5

11.7 ± 4.8

11.0 ± 5.0

 < 0.001

Endometrium thickness on hCG trigger day (mm)

10.7 ± 2.1

10.9 ± 2.0

10.8 ± 2.1

 < 0.001

Infertility type

 < 0.001

 Primary infertility

2202 (57.5%)

2102 (53.6%)

2024 (52.0%)

 Secondary infertility

1626 (42.5%)

1822 (46.4%)

1869 (48.0%)

Stimulation protocol

 < 0.001

 GnRH-agonist protocol

1884 (49.2%)

2023 (51.6%)

1608 (41.3%)

 Prolonged GnRH-agonist protocol

674 (17.6%)

884 (22.5%)

1352 (34.7%)

 GnRH-antagonist protocol

736 (19.2%)

608 (15.5%)

541 (13.9%)

 Data missing

534 (14.0%)

409 (10.4%)

392 (10.1%)

FSH total dose (IU)

1715.4 ± 369.3

2470.3 ± 187.0

3514.4 ± 582.9

 < 0.001

 FSH duration (day)

9.0 ± 2.0

10.4 ± 1.4

12.3 ± 1.9

 < 0.001

Method of fertilization

 < 0.001

IVF

2926 (76.4%)

3137 (80.0%)

3145 (80.8%)

 ICSI

887 (23.2%)

768 (19.6%)

736 (18.9%)

 IVF&ICSI

15 (0.4%)

16 (0.4%)

10 (0.3%)

Number of oocytes retrieved

10.3 ± 5.6

10.2 ± 5.1

9.3 ± 4.8

 < 0.001

Embryo stage

0.032

 Cleavage stage

3777 (99.5%)

3879 (99.6%)

3858 (99.8%)

 Blastocyst stage

19 (0.5%)

14 (0.4%)

6 (0.2%)

Number of embryos transferred

 < 0.001

 1

367 (9.6%)

274 (7.0%)

131 (2.8%)

 2

3279 (85.7%)

3365 (84.8%)

4273 (91.9%)

 3

182 (4.7%)

285 (7.2%)

246 (5.3%)

  1. Normal distribution of data was presented as mean ± standard deviation; nonnormal distribution of data was presented as median (interquartile range) and categorical data using number (percentage).
  2. BMI body mass index, FSH follicle stimulating hormone, P progesterone, E2 estradiol, LH luteinizing hormone, AFC antral follicular count, hCG human chorionic gonadotropin, GnRH gonadotropin releasing hormone, IVF in vitro fertilization, ICSI intracytoplasmic single sperm injection.
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