Figure 4

Average size of cfDNA in different length ranges. (a) 35–250 bp and (b) 35–1000 bp in cancer patients (n = 166) and healthy controls (n = 56). The Mann–Whitney, two-sided test was performed. (c) 500–10380 bp, (d) 35–10380 bp, (e) 35–250 bp depending on clinical course of disease including patients with primary (PTu, n = 137) and recurrent (RTu, n = 29) tumors. The Mann–Whitney, two-sided test was performed. (f) 35–250 bp, (g) 35–10380 bp, (h) 500–10380 bp depending on clinical course of disease including patients with primary tumors without recurrence (group I, n = 114), primary tumors with reccurence (group II, n = 19) and patients with reccurent tumors (group III, n = 29). Kruskal–Wallis Rank Sum Test followed by post hoc Dunn's test was performed. (i) 35–250 bp, (j) 35–10380 bp depending on tumor location and clinical course of disease including patients with primary tumors and with reccurent tumors: group 1 PTu (n = 7), RTu (n = 2); group 2 PTu (n = 37), RTu (n = 6); group 4 PTu (n = 4), RTu (n = 2); group 5 PTu (n = 84), RTu (n = 17); group 6 PTu (n = 4), RTu (n = 2). The Mann–Whitney, two-sided test was performed.