Table 1 Clinicopathological characteristics of high- and low- Metadherin expression groups.
Characteristics | Low expression of MTDH | High expression of MTDH | P value |
|---|---|---|---|
n | 543 | 544 | |
Pathologic T stage, n (%) | 0.135 | ||
T1 | 136 (12.5%) | 142 (13.1%) | |
T2 | 306 (28.2%) | 325 (30%) | |
T3 | 83 (7.7%) | 57 (5.3%) | |
T4 | 18 (1.7%) | 17 (1.6%) | |
Pathologic N stage, n (%) | 0.054 | ||
N0 | 263 (24.6%) | 253 (23.7%) | |
N1 | 187 (17.5%) | 172 (16.1%) | |
N2 | 45 (4.2%) | 71 (6.6%) | |
N3 | 43 (4%) | 34 (3.2%) | |
Pathologic M stage, n (%) | 0.119 | ||
M0 | 429 (46.4%) | 476 (51.5%) | |
M1 | 13 (1.4%) | 7 (0.8%) | |
Pathologic stage, n (%) | 0.432 | ||
Stage I | 95 (8.9%) | 87 (8.2%) | |
Stage II | 315 (29.6%) | 304 (28.6%) | |
Stage III | 117 (11%) | 127 (11.9%) | |
Stage IV | 12 (1.1%) | 6 (0.6%) | |
Race, n (%) | 0.138 | ||
Asian | 33 (3.3%) | 27 (2.7%) | |
Black or African American | 105 (10.5%) | 77 (7.7%) | |
White | 376 (37.7%) | 379 (38%) | |
Age, n (%) | 0.978 | ||
≤ 60 | 301 (27.7%) | 302 (27.8%) | |
> 60 | 242 (22.3%) | 242 (22.3%) | |
Histological type, n (%) | < 0.001 | ||
Infiltrating ductal carcinoma | 331 (30.9%) | 445 (41.6%) | |
Infiltrating lobular carcinoma | 149 (13.9%) | 56 (5.2%) | |
Mixed histology (please specify) | 13 (1.2%) | 16 (1.5%) | |
Mucinous carcinoma | 13 (1.2%) | 4 (0.4%) | |
Other, specify | 27 (2.5%) | 16 (1.5%) | |
PR status, n (%) | 0.354 | ||
Negative | 163 (15.8%) | 179 (17.3%) | |
Positive | 351 (33.9%) | 341 (33%) | |
ER status, n (%) | 0.425 | ||
Negative | 114 (11%) | 126 (12.2%) | |
Positive | 402 (38.8%) | 395 (38.1%) | |
HER2 status, n (%) | 0.708 | ||
Negative | 277 (38.6%) | 283 (39.5%) | |
Positive | 75 (10.5%) | 82 (11.4%) | |
Menopause status, n (%) | 0.314 | ||
Pre | 104 (10.7%) | 126 (12.9%) | |
Peri | 20 (2%) | 20 (2%) | |
Post | 360 (36.9%) | 346 (35.5%) | |
OS event, n (%) | < 0.001 | ||
Alive | 488 (44.9%) | 447 (41.1%) | |
Dead | 55 (5.1%) | 97 (8.9%) | |
DSS event, n (%) | 0.025 | ||
No | 506 (47.4%) | 476 (44.6%) | |
Yes | 33 (3.1%) | 52 (4.9%) | |
PFI event, n (%) | 0.135 | ||
No | 478 (44%) | 462 (42.5%) | |
Yes | 65 (6%) | 82 (7.5%) | |
