Table 1 Demographic and clinical characteristics of the sample.

From: Prenatal cocaine exposure and its influence on pediatric epigenetic clocks and epigenetic scores in humans

Variables

PCE (n = 35)

Controls (n = 47)

 

Median/n

IQR/%

Median/n

IQR/%

Statistics

p-val

Newborn sex (male)

16

45.7

24

51.1

χ2 = 0.230

0.632

Gestational age at birth (weeks)

39

2.9

39.2

1.9

U = 976

0.193

Apgar

9

1

10

1

U = 1061

0.017

Newborn weight (grams)

2930

695

3018

600

U = 1039

0.044

Maternal infectious disease

16

45.7

0

0

χ2 = 26.69

0.001

Maternal ethnicity (white)

10

28.6

35

74.5

χ2 = 17.06

0.001

Maternal age (years)

26

6

24

7

U = 593

0.028

CD4T cell % estimate

0.132

0.083

0.001

0.014

U = 99

 < 0.001

CD8T cell % estimate

0.134

0.078

0.067

0.037

U = 237

 < 0.001

Neutrophils cell % estimate

0.516

0.182

0.841

0.080

U = 1547

 < 0.001

Monocytes cell % estimate

0.090

0.031

0.078

0.028

U = 734

0.407

Nucleated red blood cell % estimate

0.460

0.110

0.560

0.050

U = 1426

 < 0.001

ES for maternal smoking

0.59

1.36

 − 0.44

1.08

U = 424

 < 0.001

Frequent alcohol use (last trimester)

14

40.0%

  

Frequent tobacco use (last trimester)

31

88.6%

4

8.5%

χ2 = 52.56

 < 0.001

Frequent cannabis use (last trimester)

10

28.5%

  

Frequent cocaine use (last trimester)

29

82.8%

  
  1. PCE Prenatal cocaine exposure, ES Epigenetic score, IQR Interquartile range, χ2 Chi-Square test, U Mann–Whitney U statistics.