Figure 6 | Scientific Reports

Figure 6

From: Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2

Figure 6

SEC-UPLC analysis showing conformational transition after thermal stress (37 °C) and cold storage for 8 days. (A) Percent open trimer peak area for ancestral and Beta spike protein yielding partial recovery of open trimer conformation after temperature treatment followed by cold temperature hold. (B) Canonical trimer peak area comparison for ancestral and Beta spike antigen in which Beta transitions more rapidly from open trimer to canonical conformation compared to ancestral trimer. H8D denotes 8 day hold at cold storage whereas H0 represents no hold after thermal stress.

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