Table 1 Spike trimer binding sites for ACE2 and antibodies.

From: Structural and biochemical rationale for Beta variant protein booster vaccine broad cross-neutralization of SARS-CoV-2

Binding partner

Ancestral

Beta

511

969-988 (SRLDPPEAEVQIDRLITGRL)

966-985 (SRLDPPEAEVQIDRLITGRL)

*CR3022

356-379 (YNSASFSTFKCYGVSPTKLNDLCF)

353-376 (YNSASFSTFKCYGVSPTKLNDLCF)

414-417 (DDFT)

411-414 (DDFT)

502-505 (FELL)

499-502 (FELL)

**hACE2

426 (N), 436 (Y), 440(Y), 442-3 (LF), 462 (A), 473-4 (FN), 476 (Y), 480 (Q), 482 (Y), 485 (Q), 487-9 (TNG), 492 (Y)

423 (N), 433 (Y), 437(Y), 439-440 (LF), 459 (A), 470-1 (FN), 473 (Y), 477 (Q), 479 (Y), 482 (Q), 484-6 (TYG), 489 (Y)

  1. *CR3022 epitopes22.
  2. **hACE2 binding site22.
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