Table 5 Descriptive statistics (Mean ± SD and range) of NIBUT (s) manually measured by the two observers (Obs1 and Obs 2) in the two sessions (N = 85). Paired comparisons between observers for each manual measure (Wilcoxon test in fifth row) and correlation (sixth row), as well as paired comparisons between automatic and each manual measure achieved by the two observers (Wilcoxon test, tenth and eleventh row) and correlation (Spearman Rho; twelfth and thirteenth row) are also reported.

From: Comparing automated and manual assessments of tear break-up time using different non-invasive devices and a fluorescein procedure

 

First session (Test)

Second session (Retest)

Overall average manual Mean ± SD (Range) (s)

First manual Mean ± SD (Range) (s)

Second manual Mean ± SD (Range) (s)

Third manual Mean ± SD (Range) (s)

Average Mean ± SD (Range) (s)

First manual Mean ± SD (Range) (s)

Second manual Mean ± SD (Range) (s)

Third manual Mean ± SD (Range) (s)

Average Mean ± SD (Range) (s)

Observer 1 (Obs 1)

8.2 ± 4.2 (1.9–22.7)

7.9 ± 3.9 (1.9–20.9)

7.7 ± 3.7 (1.9–19.0)

7.9 ± 3.9 (2.0–20.4)

7.3 ± 3.6 (2.0–19.2)

6.9 ± 3.5 (1.8–18.3)

6.8 ± 3.4 (2.2–18.7)

7.0 ± 3.5 (2.0–18.4)

7.5 ± 3.6 (2.0–19.0)

Observer 2 (Obs 2)

7.2 ± 3.7 (1.2–19.7)

6.5 ± 3.6 (1.5–18.6)

6.3 ± 3.4 (1.6–17.5)

6.7 ± 3.5 (1.7–17.7)

6.2 ± 3.6 (1.4–19.3)

5.8 ± 3.4 (1.0–17.1)

5.8 ± 3.3 (1.2–18.2)

6.0 ± 3.4 (1.2–17.4)

6.3 ± 3.4 (1.7–17.3)

Comparison Obs 1—Obs 2 (Wicoxon test)

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

Correlation Obs1—Obs 2 (Sperman Rho)

*0.86 (p < 0.001)

*0.85 (p < 0.001)

*0.87 (p < 0.001)

*0.89 (p < 0.001)

*0.88 (p < 0.001)

*0.90 (p < 0.001)

*0.93 (p < 0.001)

*0.92 (p < 0.001)

*0.94 (p < 0.001)

Difference between Automatic and Manual NIBUT Obs 1 (s)

− 1.6

− 1.3

− 1.2

− 1.4

− 0.8

− 0.3

− 0.3

− 0.5

− 0.9

Difference between Automatic and Manual NIBUT Obs 2 (s)

− 0.6

0.1

0.3

-0.1

0.4

0.7

0.7

0.6

0.3

Comparison Automatic-Obs 1 (Wicoxon test)

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

*p < 0.001

p = 0.03

p = 0.04

*p < 0.001

*p < 0.001

Comparison Automatic-Obs 2 (Wicoxon test)

*p = 0.003

p = 0.94

p = 0.27

p = 0.40

p = 0.07

*p < 0.001

*p < 0.001

*p < 0.001

p = 0.33

Correlation Automatic—Obs 1 (Sperman Rho)

*0.87 (p < 0.001)

*0.88 (p < 0.001)

*0.88 (p < 0.001)

*0.89 (p < 0.001)

*0.84 (p < 0.001)

*0.86 (p < 0.001)

*0.87 (p < 0.001)

*0.87 (p < 0.001)

*0.89 (p < 0.001)

Correlation Automatic—Obs 2 (Sperman Rho)

*0.84 (p < 0.001)

*0.84 (p < 0.001)

*0.85 (p < 0.001)

*0.86 (p < 0.001)

*0.83 (p < 0.001)

*0.87 (p < 0.001)

*0.88 (p < 0.001)

*0.87 (p < 0.001)

*0.89 (p < 0.001)

  1. *Significant comparisons (after Bonferroni correction for multiple comparisons, alpha was lowered to 0.017) and significant correlations are reported in bold.