Table 1 Test set performance (95% CIs in brackets) based on the average ROC across 500 bootstrap iterations given various regions of interest as input.

From: Distinguishing recurrence from radiation-induced lung injury at the time of RECIST progressive disease on post-SABR CT scans using radiomics

ROI

AUC [95% CIs]

Sensitivity [95% CIs]

Specificity [95% CIs]

Lung slice

0.58 [0.57, 0.58]ÂĄ

57% [56%, 59%]

55% [53%, 56%]

Solid and GGO approximation

0.58 [0.57, 0.59]

56% [55%, 58%]

53% [52%, 55%]

Cylinder

0.59 [0.58, 0.59]

55% [53%, 56%]

59% [57%, 60%]

Sphere (d = 40 mm)

0.59 [0.58, 0.60]

52% [50%, 53%]

60% [59%, 62%]

Sphere (d = 20 mm)

0.60 [0.59, 0.61]

57% [56%, 59%]

57% [55%, 58%]

Sphere (d = RECIST length)

0.64 [0.63, 0.65]*

57% [56%, 59%]

65% [64%, 67%]

  1. *The RECIST sphere ROI AUC is significantly different than all other ROIs (p ≤ 2.1 × 10–8).
  2. ¥The lung slice ROI is also significantly different from the 40 mm (p = 0.012) and 20 mm (p = 0.0024) sphere ROIs.
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