Figure 3
Acacetin inhibited tumor formation of NSCLC xenograft mice. (A) The changes of tumor volume. Mice were subcutaneously inoculated with A549 cells in the right flank, after the tumor volume was about 50 mm3. Mice were randomly separated into 3 groups, and acacetin was injected at 0, 10, and 20 mg/kg body weight every other day, and the tumor volume was recorded. (B, C) pictures of (B) and the weight of (C) tumor tissues isolated from mice after the last treatment (student t-test, **, p < 0.01; ***, p < 0.001; compared with 0 mg/kg group). (D) Western blotting results for apoptosis-related proteins, and cell cycle arrest-related proteins of tumor tissues (GAPDH was used as internal control for western blotting).
