Table 2 Comparison characteristics of patients with and without early recurrence.
Variables | Early recurrence | Late recurrence | No recurrence | P value |
|---|---|---|---|---|
(n = 73, 45.1%) | (n = 44, 27.2) | (n = 45, 27.8) | ||
Age, > 60 years | 48 (65.8) | 37 (84.1) | 38 (84.4) | 0.023 |
Sex (male) | 40 (54.8) | 20 (45.5) | 31 (68.9) | 0.079 |
ECOG performance status | ||||
0/1/2 | 60 (82.2)/12 (16.4)/1 (1.4) | 38 (86.4)/6 (13.6)/0 | 43 (95.6)/2 (4.4)/0 | 0.275 |
Location of cancer | 0.302 | |||
Head | 32 (43.8) | 29 (65.9) | 25 (55.6) | |
Body | 25 (34.2) | 9 (20.5) | 10 (22.2) | |
Tail | 10 (13.7) | 4 (9.1) | 8 (17.8) | |
Mixed | 6 (8.2) | 2 (4.5) | 2 (4.4) | |
Tumor size (mm) | 30.1 ± 13.5 | 29.2 ± 11.9 | 31.1 ± 20.4 | 0.810 |
Resectability | ||||
Resectable/borderline/locally advanced | 50 (68.5)/19 (26.0)/4 (5.5) | 35 (79.5)/6 (13.6)/3 (6.8) | 41 (91.1)/3 (6.7)/1 (2.2) | 0.052 |
Surgery | 0.109 | |||
Pancreaticoduodenectomy | 46 (63.0) | 23 (52.3) | 15 (33.3) | |
Distal pancreatectomy | 25 (34.2) | 19 (43.2) | 25 (55.6) | |
Total pancreatectomy | 2 (2.7) | 2 (4.5) | 4 (8.9) | |
Histological differentiation | 0.141 | |||
Well | 5 (6.8) | 3 (6.8) | 7 (15.6) | |
Moderate | 50 (68.5) | 31 (70.5) | 29 (64.4) | |
Poor | 13 (17.8) | 4 (9.1) | 2 (4.4) | |
Lymph node metastasis | < 0.001 | |||
No | 20 (27.4) | 31 (70.5) | 36 (80.0) | |
Yes | 53 (72.6) | 13 (29.5) | 9 (20.0) | |
Resection margin | 0.203 | |||
R0 | 62 (84.9) | 39 (88.6) | 43 (95.6) | |
R1 | 11 (15.1) | 5 (11.4) | 2 (4.4) | |
Neoadjuvant therapy | 0.998 | |||
Yes | 13 (17.8) | 8 (18.2) | 8 (17.8) | |
No | 60 (82.2) | 36 (81.8) | 37 (82.2) | |
Adjuvant therapy | 0.129 | |||
Yes | 53 (72.6) | 38 (86.4) | 38 (84.4) | |
No | 20 (27.4) | 6 (13.6) | 7 (15.6) | |
Laboratory variables | ||||
Pre-operative CA 19-9, ≥ 49 U/mL | 40 (56.3) | 23 (52.3) | 15 (33.3) | 0.047 |
Post-operative CA 19-9, ≥ 30 U/mL | 43 (61.4) | 20 (45.5) | 17 (37.8) | 0.054 |
Pre-operative albumin, g/dL | 3.7 ± 0.6 | 3.9 ± 0.4 | 4.0 ± 0.5 | 0.008 |
Pre-operative white blood cell count, 103/µL | 6.4 ± 2.1 | 6.0 ± 1.7 | 6.2 ± 1.7 | 0.711 |
Pre-operative lymphocyte count, 103/µL | 1.7 ± 0.7 | 1.8 ± 0.7 | 1.8 ± 0.8 | 0.375 |
Pre-operative total bilirubin, mg/dL | 1.35 ± 1.28 | 1.00 ± 0.80 | 0.98 ± 0.87 | 0.549 |
S100A2 score, ≥ 5 (n = 113) | 22 (41.5) | 17 (58.6) | 21 (67.7) | 0.053 |
