Table 3 Effect of KMP and/or 5-FU on liver function tests (A) and renal function tests (B).

Parameter	Control (0.9% Saline)	Control (0.5% CMC)	DMH	DMH/5-FU	DMH/KMP	DMH/5-FU(HD)/KMP	DMH/5-FU(LD)/KMP
(A) Liver function test
Total bilirubin (mg/dL)	0.48 ± 0.02	0.48 ± 0.01	0.07 ± 0.01^a	0.08 ± 0.02^a	0.36 ± 0.02^e,f	0.07 ± 0.01^a,h	0.21 ± 0.05^b,d,g
SGPT/ALT (U/L)	38.4 ± 0.76	37.11 ± 3.13	64.65 ± 1.64^b	98.8 ± 1.28^c,e	28.35 ± 0.03^a,d	33.31 ± 5.34^b,g	59.3 ± 5.48^b,g
SGOT/AST (U/L)	98.3 ± 2.94	97.2 ± 1.15	165.5 ± 0.8^a	205.85 ± 1.76^b,d	67.9 ± 0.69^e,f	109.93 ± 3.13 ^a,f,j	123.95 ± 4.08^a,d,i
ALP (U/L)	63.65 ± 0.25	63.2 ± 0.17	131.75 ± 25.72^c	280.5 ± 23.07^a,e	79.05 ± 6.26^c,e	96.35 ± 8.13 ^d,f,i	83 ± 18.87 ^b,d,e,i
GGT (U/L)	2.55 ± 0.49	2.6 ± 0.41	8.25 ± 1.84^a	9.6 ± 1.84^b	5.45 ± 0.37^c,d,h	3.2 ± 1.21^a,e,g	7.05 ± 0.21^a,h
(B) Renal function test
Urea (mg/dL)	32.93 ± 1.11	32.75 ± 0.89	43.52 ± 2.01^a	48.35 ± 0.86^b	41.96 ± 0.82	40.72 ± 0.81	41.42 ± 0.69
BUN (mg/dL)	15.37 ± 0.52	15.41 ± 0.46	20.31 ± 1.41^a	22.57 ± 1.61^a	20.21 ± 0.75^a	19.01 ± 0.38^a	20.25 ± 0.86^a
Serum creatinine (mg/dL)	0.42 ± 0.06	0.43 ± 0.01	0.65 ± 0.02	1.09 ± 0.28^a,d	0.46 ± 0.05	0.7 ± 0.04^a,g	0.65 ± 0.02

The values are represented as Mean ± SEM for n = 6 animals/ group.
^ap < 0.001w.r.t control group, ^bp < 0.01w.r.t control group, ^cp < 0.05w.r.t control group, ^dp < 0.001w.r.t DMH group, ^ep < 0.01w.r.t DMH group, ^fp < 0.001w.r.t DMH/5-FU group, ^gp < 0.01w.r.t DMH/5-FU group, ^hp < 0.05w.r.t DMH/5-FU group, ⁱp < 0.01 w.r.t DMH/KMP group, ^jp < 0.05 w.r.t DMH/KMP group.

Quick links

Search