Table 3 XGBoost performance on test set data for predicting 30-day primary and secondary outcomes following lower extremity open revascularization using pre-operative features.

	AUROC (95% CI)	Accuracy (95% CI)	Sensitivity	Specificity	PPV	NPV
MALE or death	0.93 (0.92–0.94)	0.86 (0.85–0.87)	0.84	0.89	0.90	0.83
Untreated loss of patency	0.90 (0.89–0.91)	0.83 (0.81–0.84)	0.81	0.85	0.86	0.79
Major reintervention	0.91 (0.89–0.93)	0.84 (0.82–0.86)	0.83	0.85	0.87	0.80
Major amputation	0.95 (0.94–0.96)	0.88 (0.87–0.89)	0.86	0.90	0.91	0.85
Death	0.96 (0.95–0.96)	0.89 (0.87–0.90)	0.87	0.90	0.90	0.87
MACE	0.93 (0.92–0.94)	0.85 (0.84–0.86)	0.84	0.86	0.88	0.85
Myocardial infarction	0.88 (0.87–0.89)	0.80 (0.79–0.82)	0.79	0.81	0.82	0.78
Stroke	0.91 (0.90–0.92)	0.83 (0.81–0.84)	0.82	0.84	0.85	0.80
Wound complication	0.90 (0.88–0.92)	0.82 (0.83–0.87)	0.82	0.83	0.86	0.79
Bleeding requiring transfusion or secondary procedure	0.92 (0.91–0.93)	0.84 (0.82–0.85)	0.82	0.86	0.87	0.81
Other morbidity	0.91 (0.89–0.92)	0.82 (0.81–0.84)	0.81	0.84	0.85	0.79
Non-home discharge	0.95 (0.95–0.96)	0.89 (0.88–0.90)	0.86	0.92	0.92	0.85
Unplanned readmission	0.87 (0.86–0.89)	0.80 (0.78–0.82)	0.80	0.77	0.77	0.81

XGBoost (Extreme Gradient Boosting), AUROC (area under the receiver operating characteristic curve), CI (confidence interval), PPV (positive predictive value), NPV (negative predictive value), MALE (major adverse limb event; composite of untreated loss of patency, major reintervention, or major amputation), MACE (major adverse cardiovascular event; composite of myocardial infarction, stroke, or death).

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