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Figure 1

From: Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling

Figure 1

EA treatment mitigates the surgical-induced suppression of IGF-1 signaling. (A) Temporal variations in hippocampal IGF-1 mRNA expression after surgery were determined using qPCR, observing changes at Baseline, and 24, 48, and 72 h post-surgery. (B) Hippocampal IGF-1 protein expression was evaluated via western blot at baseline and at 24, 48, and 72 h following surgery. (C–F) The impact of oral EA treatment on hippocampal IGF-1 and p-IGF1R levels in aged mice was assessed. The protein levels of IGF-1 and IGF1R were normalized to β-actin, and the levels of p-IGF1R were normalized to total IGF1R. The data are presented as mean ± SD. Statistical significance is indicated as *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, while 'ns' represents non-significant results.

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