Table 3 Sensitivity analysis on the association of cholecystectomy with risk of cardiovascular disease among participants with fewer or more comorbidities.

From: Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study

 

No cholecystectomy

Cholecystectomy

P value

Charlson comorbidity index < 2

 Cardiovascular disease

  Events

1069

73

 

  Person-years

93,595

5686

 

  aHR (95% CI)a

1.00 (reference)

1.03 (0.81–1.31)

0.831

Short-term (< 2 years) risk

 Cardiovascular disease

  Events

287

22

 

  Person-years

34,400

2117

 

  aHR (95% CI)a

1.00 (reference)

1.19 (0.76–1.86)

0.451

Long-term (≥ 2 years) risk

 Cardiovascular disease

  Events

782

51

 

  Person-years

93,315

5673

 

  aHR (95% CI)a

1.00 (reference)

0.97 (0.73–1.29)

0.838

Charlson comorbidity index ≥ 2

 Cardiovascular disease

  Events

2418

387

 

  Person-years

121,890

16,483

 

  aHR (95% CI)a

1.00 (reference)

1.16 (1.04–1.29)

0.007

Short-term (< 2 years) risk

 Cardiovascular disease

  Events

883

168

 

  Person-years

51,444

6748

 

  aHR (95% CI)a

1.00 (reference)

1.47 (1.24–1.73)

< 0.0001

Long-term (≥ 2 years) risk

 Cardiovascular disease

  Events

1535

219

 

  Person-years

121,028

16,354

 

  aHR (95% CI)a

1.00 (reference)

0.99 (0.86–1.15)

0.939

  1. aHazard ratios calculated by Cox proportional hazards regression analysis after adjustments for age, household income, alcohol consumption, body mass index, systolic blood pressure, fasting serum glucose, total cholesterol, Charlson comorbidity index.
  2. Significant values are in bold.
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