Table 4 Sensitivity analysis on the association of cholecystectomy with risk of cardiovascular disease among women or men.

From: Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study

 

No cholecystectomy

Cholecystectomy

p value

Women

 Cardiovascular disease

  Events

1291

159

 

  Person-years

94,133

9776

 

  aHR (95% CI)a

1.00 (reference)

1.03 (0.87–1.21)

0.755

Short-term (< 2 years) risk

 Cardiovascular disease

  Events

425

63

 

  Person-years

37,188

3842

 

  aHR (95% CI)a

1.00 (reference)

1.27 (0.97–1.66)

0.081

Long-term (≥ 2 years) risk

 Cardiovascular disease

  Events

866

96

 

  Person-years

93,712

9730

 

  aHR (95% CI)a

1.00 (reference)

0.91 (0.74–1.13)

0.413

Men

 Cardiovascular disease

  Events

2196

301

 

  Person-years

121,352

12,393

 

  aHR (95% CI)a

1.00 (reference)

1.12 (0.99–1.26)

0.084

Short-term (< 2 years) risk

 Cardiovascular disease

  Events

745

127

 

  Person-years

48,656

5023

 

  aHR (95% CI)a

1.00 (reference)

1.39 (1.15–1.69)

0.001

Long-term (≥ 2 years) risk

 Cardiovascular disease

  Events

1451

174

 

  Person-years

120,631

12,296

 

  aHR (95% CI)a

1.00 (reference)

0.97 (0.83–1.14)

0.733

  1. aHazard ratios calculated by Cox proportional hazards regression analysis after adjustments for age, household income, alcohol consumption, body mass index, systolic blood pressure, fasting serum glucose, total cholesterol, Charlson comorbidity index.
  2. Significant values are in bold.
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