Table 1 Comparison of characteristics of Patient Cohorts investigated with IgG subclass measurements by BSIN and LC–MS/MS respectively.

No. of patients

43

102

Age (mean)

63 ± 13

63 ± 14

Gender (ratio, F:M)

16:27

25:77

No. of organs affected (mean)

3

3

Responder index score (n = 82)

12.5

8.1

Organ site involvement

 Central Nervous System

  Hypophysitis

0

1

 Ophthalmic

  Lacrimal glands

10

24

  Orbital myositis

1

1

 Major salivary gland

  Parotid

9

15

  Submandibular

24

43

  Sublingual

0

3

 Ear, nose, and throat

  Sinusitis

4

15

  Nasal disease

1

1

 Pulmonary

 Pulmonary pseudotumor

0

2

 Pulmonary nodules

5

13

 Multiple ground-glass opacities

3

4

 Interstitial lung disease

1

3

 Cardiac

  Pericardial disease

2

2

  Coronary Vasculitis

2

3

 Kidney disease

  Tubulointerstitial nephritis

1

13

  Multiple kidney opacities

2

3

  Kidney pseudotumor

1

2

  Other

2

4

 Retroperitoneal fibrosis

5

11

 Aortitis

  Thoracic

2

5

  Abdominal

2

2

 Autoimmune pancreatitis

17

39

 Biliary duct disease

5

18

 Sclerosing Mesenteritis

0

4

 Prostatitis

2

5

 Lymphadenopathy

44

24

 Constitutional symptoms

2

4

 Skin disease

1

4

 Other

3

14

Laboratory Data

IgG4 Level (median ± Interquartile range)

6.14 g/L ± 8.81 g/L

3.63 g/L ± 4.83 g/L

Total IgG Level (median ± Interquartile range)

25.23 g/L ± 22.615 g/L

16.22 g/L ± 8.49 g/L