Table 6 Univariate and multivariate cox regression.

From: Identification of a novel macrophage-related prognostic signature in colorectal cancer

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
Characteristics	Total (N)	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
T stage	640
T1&T2	131	Reference
T3	435	2.047 (1.090–3.842)	0.026	1.500 (0.666–3.379)	0.328
T4	74	6.148 (3.045–12.415)	< 0.001	2.577 (1.013–6.554)	0.047
N stage	639
N0	367	Reference
N1	153	1.774 (1.131–2.781)	0.013	1.318 (0.776–2.237)	0.307
N2	119	3.873 (2.588–5.796)	< 0.001	2.487 (1.490–4.151)	< 0.001
M stage	563
M0	474	Reference
M1	89	3.989 (2.684–5.929)	< 0.001	2.135 (1.303–3.500)	0.003
ADAM8	643
High	321	Reference
Low	322	0.601 (0.423–0.853)	0.004	0.639 (0.391–1.042)	0.073
C5AR1	643
High	321	Reference
Low	322	0.715 (0.504–1.012)	0.058	0.604 (0.351–1.039)	0.069
CCL22	643
High	322	Reference
Low	321	1.871 (1.299–2.694)	< 0.001	1.531 (0.934–2.512)	0.091
CIITA	643
High	322	Reference
Low	321	1.628 (1.137–2.332)	0.008	1.130 (0.662–1.931)	0.654
CTSD	643
High	322	Reference
Low	321	0.769 (0.543–1.088)	0.137
CXCL8	643
High	321	Reference
Low	322	1.525 (1.068–2.176)	0.020	1.080 (0.658–1.775)	0.760
CXCL9	643
High	322	Reference
Low	321	1.595 (1.119–2.275)	0.010	1.238 (0.752–2.038)	0.402
FABP4	643
High	321	Reference
Low	322	0.583 (0.408–0.832)	0.003	0.824 (0.523–1.298)	0.403
MMP3	643
High	321	Reference
Low	322	1.623 (1.133–2.325)	0.008	1.404 (0.859–2.293)	0.176
MS4A1	643
High	321	Reference
Low	322	1.729 (1.204–2.484)	0.003	1.952 (1.208–3.152)	0.006
SPP1	643
High	322	Reference
Low	321	0.774 (0.547–1.096)	0.149
TIMP1	643
High	322	Reference
Low	321	0.645 (0.454–0.917)	0.015	0.830 (0.541–1.275)	0.395
WNT5A	643
High	321	Reference
Low	322	1.496 (1.046–2.138)	0.027	1.417 (0.892–2.253)	0.140

CI confidence interval.
Significant values are in bold.

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