Figure 3
From: Clinical and molecular study of radiation-induced gliomas
Molecular characterization of RIGs based on methylation profiling. T-SNE analysis demonstrated that the majority of RIG samples from our cohort clustered with the pedHGG-RTK1 subgroup. The previously published cohort of 32 RIG samples (Deng et al.) is shown here, which further validates our data. RIG samples were compared with a cohort of 170 reference samples of histologically and molecularly described CNS tumors. Abbreviations: PXA—pleomorphic xanthoastrocytoma; GBM_G34—Glioblastoma, H3.3 G34 mutant; DMG_K27—diffuse midline glioma H3 K27 mutant; pedHGG_MYCN—pediatric high-grade glioma subclass MYCN; pedHGG_RTK1a—Pediatric high-grade glioma, pediatric RTK1 type, subtype A; pedHGG_RTK1b—Pediatric high-grade glioma, pediatric RTK1 type, subtype B; pedHGG_RTK1c—Pediatric high-grade glioma, pediatric RTK1 type, subtype C; pedHGG_RTK2—Pediatric high-grade glioma, pediatric RTK2 type.
