Figure 4

NJ trees based on P1, P2, and P3 regions of the prototype sequence of all Enteroviruses B in the GenBank database with 37 E25 strains. Filled rhombus: indicates E25 prototype strain (JV-4), filled circle: E25 strains in this study. Numbers on codes indicate the bootstrap support of the node (1000 bootstrap replicate percentage). (A) P1 coding sequences; (B) P2 coding sequences; (C) P3 coding sequences. (D) Recombination breakpoints based on the whole genomes of different lineages as detected within genotypes. (E) Genomic mapping of representative strain recombination events predicted using RDP4 software for E25.