Table 1 Potential genes involved in embryo-endometrium interaction in P+ vs. NB.

From: Embryo-endometrial interaction associated with the location of the embryo during the mobility phase in mares

Upstream Regulator*

Molecule Type

z-score

p-value

Target Molecules in Dataset**

COP1

Enzyme

2.98

0.0003

CXCL10,CYP26B1,ETV4,ETV5,GPNMB,HSPB8,IL12B,PEX11A,PPARGC1A,RET

COL18A1

Other

2.76

0.01

CCND1,EPHB1,ID1,ID3,KNG1,PLAU,THBS1,TNF

CITED2

Transcription regulator

2.76

0.02

CXCL10,EGLN3,FOXP3,FUT8,GADD45B,GATA6,IL12B,KYNU,MID1,PLAU,TNF,TNFAIP3,UBD

GPS2

Transcription regulator

2.75

0.002

CCL20,CCND1,CXCL10,IL12B,PID1,RAB20,TNF,VCAM1

TP53

Transcription regulator

2.58

6.4 × 10–7

ABCC1,ABCG2,ACSL1,ADAMTSL4,AKT3,ALDH1A1,ALOX15,APOA1,ATF3,BHLHE40,BOK,CAMK2N1,CAV1,CCN2,CCND1,CDC42EP3,CENPK,COL6A2,COQ8A,CRYAB,CXCL10,CYFIP2,CYP24A1,CYP26B1,DAPK1,DHCR24,DKK3,DLX1,DNMT3A,DPYSL4,DTX1,DUSP4,DUSP5,DUSP6,EGF,EGR2,FGF7,FHL1,FHL2,FKBP1B,FOXP3,FRMD4A,FSTL1,GADD45B,GATA6,GJB3,GNAI1,HS3ST1,ID1,ID2,ID3,IFNG,IGDCC4,IGFBP3,IGFBP7,IL31RA,IRS1,ITGA2,ITGB6,LOX,LRAT,LTBP1,MAN2A1,MAPK12,MET,MIS18BP1,MYBL2,MYO10,MYO5A,NOS3,NOX4,NPNT,NPTX1,NR4A3,OAT,PBK,PCK1,PHGDH,PHLDA1,PLAU,PPARGC1A,PPIC,PPP1R13B,PRKCA,PRKG1,RGS16,ROBO1,S100A4,SALL2,SCD,SCN3B,SCTR,SHROOM3,SLC2A1,SPHK1,STEAP3,THBS1,TIMP1,TMEM43,TMSB10/TMSB4X,TNC,TNF,TNFAIP2,TNFRSF11A,TNFRSF18,TUBB3,TUBB4A,UBD,UBE2T,UGDH,VIM,VLDLR,WNT5B

NR3C1

Ligand-dependent nuclear receptor

2.49

4.9 × 10–9

ABL1,ACTN2,AQP1,BHLHE40,BOK,CAV1,CCL20,CCL22,CCN2,CCND1,CDC42EP3,CIDEC,COL6A2,COQ8A,CRYAB,CSRNP1,CXCL10,DDC,DUSP4,ERRFI1,GADD45B,GLCCI1,GRIA2,HGD,HSD11B1,HSD11B2,IFNG,IGFBP1,IL12B,IL1RAP,ITGB6,LOX,MFSD2A,NFIL3,NOS3,OAT,PC,PCK1,PHLDA2,PLAGL1,PLAT,RAPGEF4,RELT,RGS2,S100G,SDS,SERPINA6,SERTAD2,SLC38A1,SLC43A1,SOX4,STC1,THBS1,TIMP1,TNF,TNFAIP2,TNFAIP3,VCAM1,VIM,WNT5A

CREM

Transcription regulator

2.44

0.0001

ATF3,BHLHE40,CCND1,CSRNP1,DUSP4,EGR2,ERRFI1,GADD45B,IFNG,NFIL3,NFKBID,NR4A1,NR4A2,PCSK1,THBS1,TNF

PDX1

Transcription regulator

2.38

3.6 × 10–7

ACE2,ATF3,CAMK2N1,CCND1,DUSP5,DUSP6,EPHB1,GCH1,HAP1,ID1,ID2,ID3,IGFBP3,NPTX2,PC,PCSK1,PHGDH,PRSS23,S100G,SLC2A1,ST18,TSPAN8,WFS1

KDM5B

Transcription regulator

2.34

0.002

CAV1,CCN2,CCND1,DHCR24,FHL1,FJX1,ID2,PBK,PDE3B,PIR,SOX4,TUBB2A,WNT7B

INSIG1

other

2.33

0.01

ATF3,CCL22,CXCL10,DHCR24,IFNG,IL12B,LIPA,PLD1,SCD

SPRY2

Other

2.28

0.00002

CAV1,CCL20,CXCL10,DUSP6,ETV4,ETV5,ID2,IFNG,IGFBP3,ITGA2,MET,MYCN,SATB1,SLC2A1

PRKAA1

Kinase

2.24

4.8 × 10–9

ATF3,CA2,CDC42EP3,EGF,EGLN3,HSD3B2,ID2,IFNG,IL12B,KLHL29,MMP16,OAT,PARP3,PLA2G2A,PPARGC1A,RGS2,RHOU,RTN4RL1,SLC2A1,SPRED2,THRSP,TNF,TNS1,VCAM1,ZNF462

SAV1

Other

2.23

0.001

CCN2,CCND1,SOX4,TNF,VIM

DNASE2

Enzyme

2.21

0.004

ACKR4,CXCL10,GPNMB,IFNG,TNF

SERPINF1

Other

2.2

0.004

CCN2,CCND1,CRYAB,CSPG4,PPARGC1A,THBS1,VIM

TNFAIP3

Enzyme

2.17

0.01

CCL20,CXCL10,IFNG,TNF,TNFAIP3,VCAM1

TIA1

Other

2.13

0.007

AGR2,CCN2,CD109,GATA6,PPARGC1A,S100A6,TIMP1,TNF

DICER1

Enzyme

2.06

0.001

CCND1,CXCL10,DEPP1,DHCR24,EGR2,FOXP3,ID3,IFNG,ITGA2,KRAS,NOS3,PLAU,PRKCA,RET,RGCC,RGS5,SPRY2,THBS1,TNF,VIM,WNT5A,WNT7B

CD38

Enzyme

2.00

0.03

CCL22,EGLN3,LRRC8C,NFIL3,NOX4,PPARGC1A,S100A4,S100A6,SLC2A1,VCAM1,VIM

  1. *Upstream regulators: Common upstream regulators found in this study and were also expressed in the D12 embryo in a previous study (Vegas 2022). These upstream regulators could be potentially originate from the mobile embryo and trigger changes genes in the endometrium (target genes).
  2. **Target molecules in dataset: Genes found in this study that are potentially affected by the upstream regulators.
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