Figure 4 | Scientific Reports

Figure 4

From: Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

Figure 4

The in vitro effects of drugs on KCNT1 channels. (a) The average normalised WT KCNT1 current amplitude measured at 10 mV using I–V plots similar to those shown in Fig. 3b in the presence of the drugs. (b) The dose dependent inhibition of the WT and mutant KCNT1 channels by CBD. The curves represent the fit of the Hill equation (Eq. 1, Methods) to the experimental data. (c) The time course of KCNT1 inhibition by 10 µM CBD followed by the washout. Each point represents current amplitude measured at 10 mV from the I–V plots (see Fig. 3b) in response to the voltage ramps applied every 2 s.

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