Figure 5 | Scientific Reports

Figure 5

From: Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

Figure 5

The effect of CBD on single WT and mutant (R928C) KCNT1 channels. Single WT (a–c) and mutant channel currents (d–f) were recorded at 0 mV in inside-out patches under control conditions and in the presence of the indicated amounts of CBD in the bath. The insets show the all-point amplitude histograms of the corresponding traces. C denotes the closed state, O1 and O2 are open states corresponding to the opening of one or two KCNT1 channels, whereas S1 is a substate.

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