Table 3 Multivariate Binary Logistic Regression Analysis of Outcomes Stratified by Sex-Specific HDL Quartiles.

From: Association between HDL levels and stroke outcomes in the Arab population

Sex-specific HDL Cut-offs

Low HDL (n = 658)

Low-Normal HDL (n = 722)

High-Normal HDL (n = 309)

High HDL (n = 400)

M: ≤ 0.80 F: ≤ 1.00

M: 0.80–1.00 F: 1.00–1.30

M: 1.00–1.12 F: 1.30–1.60

M: > 1.12 F: > 1.60

Inpatient outcomes

aOR [95% CI]

p

aOR [95% CI]

p

aOR [95% CI]

p

  

In-hospital mortality

0.66 [0.25–1.75]

0.404

0.47 [0.17–1.32]

0.154

0.67 [0.21–2.18]

0.508

Ref

In-hospital complications

0.92 [0.56–1.50]

0.725

0.91 [0.56–1.49]

0.721

0.68 [0.37–1.25]

0.210

Ref

Long-term outcomes

aOR [95% CI]

p

aOR [95% CI]

p

aOR [95% CI]

p

  

1-year stroke recurrence

2.24 [1.07–4.73]

0.034*

1.07 [0.48–2.37]

0.874

1.14 [0.43–2.99]

0.791

Ref

90-day mortality

1.82 [0.66–5.02]

0.249

2.11 [0.78–5.71]

0.143

1.89 [0.62–5.81]

0.264

Ref

1-year mortality

1.96 [0.85–4.52]

0.114

2.27 [1.03–5.12]

0.049*

2.27 [0.91–5.63]

0.078

Ref

1-year post-stroke MACE

1.99 [1.19–3.31]

0.009*

1.44 [0.86–2.42]

0.166

1.55 [0.86–2.80]

0.148

Ref

1-year Post-stroke Cardiac Revascularization

1.28 [0.22–7.56]

0.785

1.27 [0.22–7.39]

0.789

2.54 [0.40–16.16]

0.324

Ref

  1. HDL high-density lipoprotein, LOS length of stay, d days, IQR interquartile range, ICU intensive care unit, MRS modified Rankin Scale, MACE major adverse cardiac event, MI myocardial infarction, aOR adjusted odds ratio, 95% CI 95% confidence interval, M males, F females.
  2. Multivariate analyses adjusted for patient demographics (age, sex, ethnicity), emergency department vitals (systolic blood pressure), comorbidities (diabetes, hypertension, dyslipidemia, coronary artery disease, atrial fibrillation, prior stroke history, obesity, smoking status), stroke severity, and in-hospital interventions (thrombolysis or thrombectomy).