Table 4 Comparison of Post-Stroke Outcomes in Different HDL Quartiles, previously published studies.
From: Association between HDL levels and stroke outcomes in the Arab population
Study | Study type, sample size, ethnicity | Follow-up duration | HDL quartiles (mmol/L) | Post-stroke outcomes (MT rate, post-stroke mortality, stroke recurrence, post-stroke MACE) |
|---|---|---|---|---|
Our study 2023 | Retrospective analysis of prospectively collected data N = 2089 Arab | 1 year | L: M ≤ 0.80, F ≤ 1.00 | 1-year stroke recurrence: aOR 2.24 95% CI 1.07–4.73, p = 0.034* 1-year mortality: aOR 2.27, 95% CI 1.03–5.12, p = 0.049* 1-year post-stroke MACE: aOR 1.99, 95% CI1.19–3.31, p = 0.009* lower HDL-C was associated with higher MT rates 5.2% vs. 2.8%; p = 0.026* |
LN: M: 0.80–1.00, F: 1.00–1.30 | ||||
HN: M: 1.00–1.12 F: 1.30–1.60 | ||||
H: M: > 1.12 (Ref.) F: > 1.60 (Ref.) | ||||
Mei et al. 2014 | Prospective N = 1059 Chinese | 4 years | H: ≥ 1.55 Moderate:1.04–1.54 L : < 1.04 | Stroke recurrence: HDL-C ≤ 1.0 (HR = 1.944, 95% CI:1.033- 3.659, P = 0.039*) HDL-C 1.01—1.19 (HR = 2.027, 95% CI:1.116–3.682, P = 0.020*) |
Kuwashiro et al. 2012 | Prospective N = 260 Japanese | 1 year | H: > 40 mg/dl L: < 40 mg/dl | Stroke recurrence: OR 2.73; 95% CI: 1.01–7.38; p = .048* |
C.-W. Liou et al. 2008 | Prospective N = 1062 Vietnamese | 1 year | L: M: < 40 mg/dl F: < 50 mg/dl | Stroke recurrence: Low HDL (OR, 1.43; 95% CI: 1.08– 1.88, p = 0.011*) |
Amarenco et al. 2008 | Randomized controlled trial N = 4731 USA | 4.9 years | 1st tertile: 0.23–1.09 2nd tertile: 1.11–1.37 3rd tertile: 1.39–3.21 | Stroke recurrence: By 1 s.d HDL increment (HR = 0.90, 95% CI: 0.82–0.99, p = 0.03*) MACE: By 1 s.d HDL increment (HR = 0.91, 95% CI: 0.83–0.99, p = 0.021*) |
Park et al. 2014 | Analysis of Randomzied controlled trial data N = 3680 USA, Canada, Scotland | 2 years | Data not shown | lowest HDL-C quintile was not associated with Recurrent stroke or MACE after multivariable Cox analyses Data not shown |
Vitturi et al. 2021 | Prospective N = 588 Brazilian | 2 years | L: M: < 40 mg/dl F: < 50 mg/dl | Stroke recurrence: OR 0.76, C.I 0.41–1.39, p = 0.47 MACE: OR 5.96, C.I 1.66–21.39, p = 0.005* |
Schwedhelm et al. 2022 | Prospective N = 681 German | 1 year | H: > 49 mg/dl L: < 49 mg/dl | MACE HR = 0.71, 95% CI 0.30–1.71, p = 0.446 |
Pedrovic et al. 2016 | Prospective N = 110 Croatian | 11 Days | Data not shown | Low HDL at discharge was associated with Barthel Index† < 60 OR 0.049, CI 0.003–0.704, p = 0.038* |
Tian et al 2013 | Cross-sectional N = 1568 Chinese | Hospital discharge | H: > 1.04 mmol/L L: < 1.04 mmol/L | Low HDL was associated with NIHSS > 10 at discharge or death OR 0.482, CI 0.235–0.946 |
Bravi et al. 2023 | Retrospective N = 1639 Italian | 5 years | Data not shown | MT patients showed lower levels of Non-HDL-C 117 mg/dl [IQR; 94–145] vs. 127 mg/dl [IQR; 103–154], P < 0.001* |
