Figure 6 | Scientific Reports

Figure 6

From: Indole-3-carbinol (I3C) reduces apoptosis and improves neurological function after cerebral ischemia–reperfusion injury by modulating microglia inflammation

Figure 6

Effect of I3C on OGD/R-induced inflammatory parameters in HAPI microglia. PCR analysis revealed that (A,B) I3C pretreatment inhibited OGD/R-induced IL-1β (A) (n = 3, ***p < 0.001 vs OGD/R) and IL-6 (B) (n = 3, ****p < 0. 001 vs OGD/ R) expression and enhanced the increased mRNA expression levels of IL-4 (C) and IL-10 (D) (n = 3, ****p < 0.0001 vs OGD/R). Data are expressed as mean ± SEM. (E) ELISA results of IL1β expression levels in HAPI microglial cell culture medium. (F) ELISA results of IL10 expression levels in HAPI microglial cell culture medium. P-values were calculated using one-way· ANOVA. n.s. p ≥ 0.05,*p < 0.05,**p < 0.01,.***p < 0.001,****p < 0.0001.

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