Figure 2 | Scientific Reports

Figure 2

From: HIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process

Figure 2The alternative text for this image may have been generated using AI.

The role of hypoxia-related genes in hypoxic condition. (a) The area under the curve for four diagnostic models. (b) The mRNA expression level of TGFBI, AKAP12, GPC1 and TGM2 in normoxia and hypoxia condition. (c) The mRNA expression level of TGFBI, AKAP12, GPC1 and TGM2 after transfected with HIF1a-plasmid. (d) The mRNA expression level of TGFBI, AKAP12, GPC1 and TGM2 after transfected with HIF2a-lentivirus. (e) The protein expression level of TGFBI after transfected with siHIF2a. (f) The Pearson and Spearman correlation analysis of TGFBI and EPAS1. (g) The promotor region of TGFBI and binding motif of HIF2a. (h) Expression level of TGFBI in ovarian cancer and normal tissues. (i) K–M survival curves of TGFBI in ovarian cancer. (j–m) Validation of TGFBI at the translational level using the Human Protein Atlas (HPA) database (IHC).

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