Figure 1

Single-injection, low GBCA dose interleaved DCE-MRI protocol. (A) Protocol for the interleaved low GBCA dose high-temporal, high-spatial (HT-HS) interleaved DCE-MRI acquisition. (B) Contrast agent concentration–time course measured from a region-of-interest in the superior sagittal sinus. The arterial phase of the concentration–time course is sampled using fifty dynamic HT frames at the start of the acquisition to allow for accurate discrimination between plasma volume and plasma-leakage effects. Later concentration–time points are sampled using twelve pairs of interleaved low-dose LDHS & LDHT series segments. BL Baseline frame, HS High-spatial, HT High-temporal, LD Low-dose, LDHS Low-dose high-spatial, LDHT low-dose high-temporal.