Figure 8
From: Low-dose GBCA administration for brain tumour dynamic contrast enhanced MRI: a feasibility study
Comparison of derived ve estimates from the single low-dose DCE-MRI acquisition against tissue-derived cell density. (A) Inter-tumour scatterplot comparison of LEGATOSLDHS derived mean tumour ve estimates against H&E cell density (nuclei/× 20 HPF). Spearman’s rho reported. Data from ten tumours shown. (B) Representative image sections of a VS with high ve estimates (left) and a VS with low ve estimates (right). From top: T1W post contrast; parametric ve map; and magnification image demonstrating voxelwise heterogeneity in ve estimates across the tumour. (C) Representative haematoxylin and eosin (H&E, × 20 HPF)–stained sections from the tumour with high ve (top row) and low ve (bottom row) respectively. Mean tumour ve values for the VS displayed in Panels B and C are outlined in the scatterplot shown in Panel A with a red and blue box, respectively. HPF High-powered-field.
