Figure 3 | Scientific Reports

Figure 3

From: Montelukast, an available and safe anti-asthmatic drug, prevents maladaptive remodelling and maintains cardiac functionality following myocardial infarction

Figure 3

Montelukast prevents hypertrophy of cardiomyocytes. (A) Representative images of wheat germ agglutinin staining in the remote myocardium from SHAM, MI and MI + MTK mice at week 4 post-surgery. Scale bar 100 \(\upmu\)m. The bar graph is related to the cross-sectional area (CSA), which was significantly counteracted by montelukast (n = 3–5/group). (B) Western blot analysis of GSK3β of cardiac sample from remote zone at week 4 post-surgery (n = 3–6/group). The blots were cropped from different parts of the same gel as delineated with dividing white space. The original images of full-length blots cannot be provided because the blots were cut prior to hybridisation with antibodies. Gels and blots with molecular size marker and membrane edges visible are presented in supplementary information and the regions of the original blots used in main figures were denoted using red boxes (Fig. 1S–5S). Data are expressed as mean ± SEM. One-way ANOVA analysis followed by Dunnett's Multiple Comparison Test, * p < 0.05; ** p < 0.01 and *** p < 0.001 versus MI.

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