Table 2 Methadone dose and pain score for each genotype.

From: The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life

Outcome

Genotype frequency

Test statistic

p value

A/A

n = 34 (73.9%)

A/G

n = 11 (23.9%)

G/G

n = 1 (2.2%)

A/G+G/G

n = 12 (26.1%)

Methadone dose (mg/day)

Median (IQR) (min, max)

15 (12.8) (5, 58.3)

7.7 (17.9) (3.8, 93.3)

5.0

7.6 ± 14.4 (3.8, 93.3)

H = 2.121

0.145a

Pain score (0–10)

Median (IQR) (min, max)

3.8 (3.3) (0, 8)

4.0 (2.0) (0, 5.7)

2.3

3.9 ± 1.9 (0, 5.7)

H = 0.347

0.556a

Low pain score (≤ 3/10)

n (%)

15 (44.1)

4 (36.4)

1 (100)

5 (41.7)

χ2 = 0.022

0.883b

High pain score (> 3/10)

n (%)

19 (55.9)

7 (63.6)

0 (0)

7 (58.3)

  1. aKruskal-Wallis H test.
  2. bχ2 test for association of methadone dose or pain score with genotype A/A compared to A/G+G/G.
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