Figure 4
From: New role of fat-free mass in cancer risk linked with genetic predisposition
Pleiotropic haplotypes associated with both post-menopausal breast cancer and anthropometric measures. Genetic association analysis of quantitative (anthropometric measures) and dichotomous (cancer occurrence) variables were carried out under an additive model in PLINK using the UK Biobank genetic data. Age and genetic principal components (1–10 PCs) were used as covariates to control for hidden population structure in the GWAS of all phenotypes investigated. Pleiotropic lead SNPs that have significant associations with both post-menopausal breast cancer (PMBC) and anthropometric measures (association p < 3.08E-6 on both phenotypes) are shown. WBFFM whole body fat-free mass, WBFM whole body fat mass, BMI body mass index.
