Table 2 Association between periods of TI prophylaxis and post-treatment hepatotoxicity.

From: Evaluate the value of prolonging the duration of tiopronin for injection administration in preventing hepatotoxicity

 

OR (95% CI)

P-value

Crude model

 TI prophylaxis for ≥ 5 days

 

0.703

 TI prophylaxis for 1 day

1.794 (0.657–4.899)

0.254

 TI prophylaxis for 2 days

0.883 (0.420–1.857)

0.744

 TI prophylaxis for 3 days

0.945 (0.479–1.866)

0.871

 TI prophylaxis for 4 days

0.978 (0.467–2.044)

0.952

Model 1

 TI prophylaxis for ≥ 5 days

 

0.428

 TI prophylaxis for 1 day

3.186 (0.978–10.386)

0.055

 TI prophylaxis for 2 days

1.740 (0.618–4.898)

0.294

 TI prophylaxis for 3 days

1.600 (0.662–3.865)

0.296

 TI prophylaxis for 4 days

1.338 (0.593–3.017)

0.483

Model 2

 TI prophylaxis for ≥ 5 days

 

0.432

 TI prophylaxis for 1 day

3.175 (0.972–10.367)

0.056

 TI prophylaxis for 2 days

1.732 (0.613–4.890)

0.300

 TI prophylaxis for 3 days

1.596 (0.660–3.861)

0.299

 TI prophylaxis for 4 days

1.344 (0.591–3.013)

0.488

Model 3

 TI prophylaxis for ≥ 5 days

 

0.292

 TI prophylaxis for 1 day

3.534 (1.061–11.765)

0.040

 TI prophylaxis for 2 days

2.067 (0.722–5.921)

0.176

 TI prophylaxis for 3 days

1.580 (0.648–3.853)

0.314

 TI prophylaxis for 4 days

1.246 (0.547–2.842)

0.601

  1. Model 1: adjusted for duration of chemotherapy drugs; Model 2: adjusted for duration of chemotherapy drugs and combinations of chemotherapeutic drugs; Model 3: adjusted for duration of chemotherapy drugs, combinations of chemotherapeutic drugs, and past history of hepatotoxicity. Bold type-statistically significant.