Table 4 Relationship between the periods of TI prophylaxis and post-treatment hepatotoxicity by past history of hepatotoxicity.
Crude model | Model 1 | Model 2 | |
|---|---|---|---|
Past history of hepatotoxicity (−) P-value/OR (95% CI) | |||
TI prophylaxis for ≥ 5 days | 0.451 | 0.436 | 0.406 |
TI prophylaxis for 1 day | 0.282/2.031 (0.558–7.388) | 0.098/3.744 (0.783–17.892) | 0.087/3.931 (0.821–18.811) |
TI prophylaxis for 2 days | 0.518/0.717 (0.261–1.968) | 0.593/1.482 (0.350–6.267) | 0.562/1.530 (0.363–6.442) |
TI prophylaxis for 3 days | 0.458/0.688 (0.256–1.847) | 0.766/1.214 (0.339–4.350) | 0.749/1.231 (0,344–4.404) |
TI prophylaxis for 4 days | 0.970/1.020 (0.358–2.905) | 0.528/1.455 (0.453–4.673) | 0.513/1.476 (0.460–4.732) |
Past history of hepatotoxicity (+) P-value/OR (95% CI) | |||
TI prophylaxis for ≥ 5 days | 0.720 | 0.487 | 0.516 |
TI prophylaxis for 1 day | 0.551/1.650 (0.319–8.542) | 0.281/2.809 (0.429–18.392) | 0.287/2.790 (0.422–18.428) |
TI prophylaxis for 2 days | 0.338/1.768 (0.552–5.665) | 0.136/3.250 (0.689–15.324) | 0.163/3.058 (0.636–14.705) |
TI prophylaxis for 3 days | 0.695/1.215 (0.459–3.214) | 0.298/1.949 (0.555–6.846) | 0.321/1.898 (0.535–6.732) |
TI prophylaxis for 4 days | 0.786/0.864 (0.301–2.483) | 0.845/1.122 (0.356–3.531) | 0.886/1.088 (0.343–3.456) |
