Table 4 Correlation of odor identification scores with neuropsychological test results and CSF biomarker levels in selected categories of the A/T/N classification (A−/T−/N−, A+/T−/N−, A+/T+/N−, and A+/T+/N+), both in the presence and absence of ApoE4.

	Total		ApoE4(+)		ApoE4(−)
	rho	P-value	rho	P-value	rho	P-value
Neuropsychological Test
MMSE	0.517	< 0.0001	0.258	0.194	0.425	0.0019
ADAS-cog J	− 0.551	< 0.0001	− 0.222	0.267	− 0.468	0.0006
FAB	0.509	< 0.0001	0.001	0.996	0.584	< 0.0001
GDS	− 0.014	0.907	0.052	0.798	− 0.035	0.809
WMS-R Attention/Concentration score	0.381	0.001	0.175	0.404	0.467	0.0007
WMS-R Delayed recall score	0.576	< 0.0001	0.259	0.212	0.526	0.0001
WMS-R Logical Memory II score	0.578	< 0.0001	0.386	0.047	0.464	0.0008
CSF biomarkers
Aβ40	0.027	0.8132	0.020	0.922	− 0.006	0.9685
Aβ42	0.386	0.0005	0.216	0.280	0.252	0.0739
Aβ42/40 ratio	0.425	0.0001	0.305	0.122	0.317	0.0235
p-Tau	− 0.373	0.0008	− 0.387	0.046	− 0.143	0.3172
t-Tau	− 0.229	0.0435	− 0.285	0.150	− 0.088	0.5416
p-Tau /Aβ42 ratio	− 0.432	< 0.0001	− 0.418	0.030	− 0.250	0.0775
p-Tau/t-Tau ratio	− 0.129	0.2615	− 0.152	0.450	− 0.021	0.885

Significant correlations were found between odor identification scores and the main neuropsychological tests (MMSE, ADAS-cog J, FAB, Attention/Concentration, Delayed recall, and Logical memory II) using Spearman rank correlation and between olfactory performance and CSF markers (Aβ42, Aβ42/40 ratio, p-Tau, t-Tau, and p-Tau/Aβ42).
A (+) amyloid-positive individuals with A/T/N classification; A (−) amyloid-negative; T (+) p-Tau positive; T (−) p-Tau negative; N (+) t-Tau positive; N (−) t-Tau negative; AUC area under the curve; CSF cerebrospinal fluid; MMSE Mini-Mental State Examination; WMS-R Wechsler Memory Scale-revised; ADAS-cog J Alzheimer-Disease Assessment Scale-Cognitive-Japanese version.
Significant values are in [bold].

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