Table 8 Comparison of odor identification scores between the standard version and the selected version among individuals with normal biomarkers and those in the AD continuum.

From: Odor identification score as an alternative method for early identification of amyloidogenesis in Alzheimer’s disease

 

Group 1

Group 2

Mean (SD) (Group 1/Group 2)

P-value (mean)

AUC

95% CI (De Long)

Cut-off

Specificity

Sensitivity

P-value (AUC)

Standard version (12 items)

A − T − N − 

A + T − N−,A + T + N−, A + T + N + 

6.7(2.2)/4.5(2.1)

 < .0001*

0.761

0.658–0.864

5.5

0.676

0.659

0.265

Selected version (4 items***)

A − T − N − 

A + T − N− ,A + T + N−, A + T + N + 

2.8(0.7)/1.7(0.9)

 < .0001**

0.809

0.718–0.900

2.5

0.676

0.854

 
  1. This analysis compared a 12-item standard version with a 4-item selected version in an odor identification test between individuals with normal biomarkers and those within the selected Alzheimer's disease continuum. The mean values for both groups showed significant differences between the standard (Group 1: 6.7, Group 2: 4.5) and selected versions (Group 1: 2.8, Group 2: 1.7). Both versions exhibited statistical significance (p < .0001) in this comparison. The selected version demonstrated an improved area under the curve (AUC) of 0.809 (95% CI: 0.718–0.900) compared to the standard version's AUC of 0.761 (95% CI: 0.658–0.864). Notably, the selected version displayed a lower cutoff value (2.5) with higher sensitivity (0.854), indicating potential advantages over the standard version in diagnostic performance.
  2. SD standard deviation; AUC area under the curve.
  3. *T test; **Wilcoxon rank sum test, *** A: India ink, B: wood, F: curry, J: sweaty socks.
Back to article page