Table 6 Multivariate cox regression analyses of survival surrogates (clinical response and pathologic response) in the PP population (n = 141).

From: Efficacy of neoadjuvant immunochemotherapy and survival surrogate analysis of neoadjuvant treatment in IB–IIIB lung squamous cell carcinoma

Survival surrogate

DFS

OS

HR

95%CI

P-value

C-index

95%CI

HR

95%CI

P-value

C-index

95%CI

Clinical response (CR/PR vs SD)

0.792

0.445–1.407

0.426

0.563

0.462–0.664

0.906

0.460–1.784

0.776

0.542

0.431–0.653

Pathologic response (pCR vs non-pCR)

0.695

0.212–2.280

0.548

0.672

0.583–0.762

0.849

0.790–3.798

0.831

0.659

0.563–0.754

Pathologic response (MPR vs non-MPR)

0.325

0.127–0.833

0.019

0.730

0.642–0.818

0.906

0.092–1.008

0.051

0.722

0.628–0.816

  1. PP, postoperative; DFS, disease-free survival; OS, overall survival; HR, hazard ratio; CI, confidence interval; CR, complete remission; PR, partial remission; SD, stable disease; MPR, major pathologic response; pCR, pathologic complete response.
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