Table 1 Mean Drug Sensitivity Scores, DSS3, of pre-B-ALL cell lines to a panel of autophagy and lysosomal inhibitors (n = 3).
From: Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
DRUG/Compound | COG-LL-355h | REH | MHH-CALL-2 | RCH-ACV | SEM | KASUMI-9 |
|---|---|---|---|---|---|---|
Chloroquine | 22.5 | 28.3 | 20.6 | 9.5 | 5.3 | 2.1 |
Hydroxychloroquine | 19 | 13.4 | 11.1 | 10.1 | 1.7 | 4 |
LYS-05 | 29.5 | 21.1 | 15 | 15.4 | 6.4 | 5.3 |
PIK-III | 29 | 27.6 | 21 | 22 | 20.7 | 7.6 |
SAR405 | 7 | 8.9 | 10.7 | 14.5 | 11 | 4.3 |
ULK-101 | 1.4 | 4.3 | 2.8 | 0 | 28.1 | 4.4 |
L309-1226 | 21.6 | 16.5 | 9.4 | 7.2 | 11.1 | 4.8 |
