Figure 1

Examples for region of interest (ROI) placements in polychromatic (1st and 3rd images from left) as well as corresponding virtual non-contrast (2nd and 4th images from left) images for net water uptake measurements. The ischemic infarction (Red) was compared to the corresponding unaffected contralateral region (green). Top row: Follow-up dual-energy CT within 16 h in an 84-year-old female with right middle cerebral artery (MCA) occlusion (initial NHISS 20; ASPECTS 7) after thrombectomy (mTICI 0). Example to demonstrate how visually apparent hyperattenuations in conventional polychromatic images (CP-I) were spared during ROI placement. Edema underestimation was 12.8%. Bottom row: Follow-up dual-layer dual-energy CT within 16 h in a 69-year-old man with right MCA occlusion (initial NHISS 17; ASPECTS 4) after thrombectomy (mTICI 2b). Example of ischemic ROI placement if no visually apparent hyperattenuations were seen on CP-I. Edema underestimation was 4.5%.