Table 3 Mean retinal sensitivities of various pathological AMD lesions.

From: Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

 

Number of eyes

Number of eyes #

Mean area mm2 (SD)

Mean number of sensitivity points

Mean retinal sensitivity dB (SD)

Total lesion area

140

134

14.6(11.6)

16.4

16.9(8.4)

Peri-lesional areas @

140

140

4.4(2.3)

6.6

20.2(7.6)

Structurally normal areas§3

162

160

130.6(11.9)

17.5

22.2(7.0)

Pathological structures

 Atrophy

31

27

4.4(4.4)

5.9

6.2(7.0)

 Fibrosis

34

33

5.3(7.5)

6.9

5.5(5.4)

Drusen and PED

131

126

12.4(10.8)

14.4

17.7(8.0)

SRF

33

31

5.4(5.5)

7.0

12.9(7.7)

IRF

26

23

3.3(3.4)

6.0

7.7(7.2)

NV

46

46

8.5(5.2)

11.6

13.2(8.7)

Early and acute lesions (SRF, IRF, PED, NV)

140

127

12.8(10.9)

15.4

17.9(7.9)

Late and chronic lesions (Fibrosis, atrophy)

51

49

6.0(7.6)

7.5

6.4(6.2)

  1. AMD age related macular degeneration, PED pigment epithelial detachment, SRF subretinal fluid, IRF Intraretinal fluid, NV neovascularization, MP microperimetry, RSP retinal sensitivity points.
  2. #Our multimodal imaging overlay algorithm only took into account MP RSP that intersected lesion masks by at least 10%. Hence, there are some eyes with lesion areas that had insufficient or no areas of intersection with MP RSP, thus did not yield any data for analysis. One example would be eyes with only drusens and PED which are too small in size.
  3. @Peri-lesional areas referred to 1 degree of visual angle (0.3 mm border thickness) from boundaries of AMD-related pathological lesions (Fig. 1).
  4. §Structurally normal areas referred to areas of the retina in AMD eyes with no apparent pathological lesions, i.e. excluding lesion areas and peri-lesional areas.
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