Table 4 Unadjusted and adjusted odds ratio of mean retinal sensitivities of pathological AMD-lesions compared to normal controls.

From: Defining the structure–function relationship of specific lesions in early and advanced age-related macular degeneration

 

Univariable

Multivariable

Odds ratioå

95% CI

P-value*

Odds ratioå

95% CI

P-value*

Total lesion area

0.80

0.72,0.89

 < 0.01

0.81

0.73,0.91

 < 0.01

Structurally normal areas§

1.17

1.02,1.33

0.02

1.13

0.98,1.30

0.10

Atrophy

0.68

0.59,0.77

 < 0.01

0.69

0.59,0.80

 < 0.01

Fibrosis

0.67

0.59,0.77

 < 0.01

0.66

0.57,0.77

 < 0.01

Drusen and PED

0.80

0.71,0.89

 < 0.01

0.80

0.72,0.90

 < 0.01

SRF

0.71

0.61,0.81

 < 0.01

0.73

0.63,0.84

 < 0.01

IRF

0.72

0.63,0.82

 < 0.01

0.73

0.64,0.84

 < 0.01

NV

0.78

0.69,0.87

 < 0.01

0.78

0.69,0.89

 < 0.01

Early acute lesions (SRF, IRF, PED, NV)

0.80

0.72,0.90

 < 0.01

0.81

0.73,0.91

 < 0.01

Late chronic lesions (fibrosis, atrophy)

0.68

0.60,0.77

 < 0.01

0.68

0.60,0.78

 < 0.01

  1. PED pigment epithelial detachment, SRF subretinal fluid, IRF intraretinal fluid, NV neovascularization.
  2. *P-value calculated by unpaired t-test.
  3. §Structurally normal areas referred to areas of the retina in AMD eyes with no apparent pathological lesions, i.e. excluding lesion areas and peri-lesional areas.
  4. åOdds ratio calculated as exponential of coefficients.