Figure 2 | Scientific Reports

Figure 2

From: The gephyrin scaffold modulates cortical layer 2/3 pyramidal neuron responsiveness to single whisker stimulation

Figure 2

GABAergic neurotransmission affected by gephyrin mutant (A) Example traces from L2/3 pyramidal cells expressing gephyrin variants or GFP (control). Colored traces: averaged currents from one neuron. Grey traces: all events measured from one neuron. (B) Miniature inhibitory postsynaptic currents (mIPSCs) amplitude. (C) inter-event interval (IEI) in L2/3 pyramidal neurons expressing individual gephyrin variants. Data are reported as mean ± SEM. Statistics: eGFP, n = 23; K148R, n = 13; gephyrin-DN, n = 13; gephyrin-SSA, n = 10 neurons, from 4–5 mice in each group. One-way ANOVA with Tukey post-hoc test. Bars: mean ± SEM. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001.

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