Table 2 Summary of the effects of different mutants used in this study.
Mutation | IPSCs | Ca2+ events | GABAAR subunits | Conclusion |
|---|---|---|---|---|
Gephyrin K148R | No change in mIPSCs | ↓ Spontaneous duration | ↑ α1 clusters | Minor effect on inhibition |
Gephryin SSA | ↑ mIPSC | ↓ Amplitude | ↓ α2 colocalization at baseline | ↑ Inhibition |
↓ # Events | ||||
Gephryin DN | ↓ mIPSCs | ↑ # of events, ↑ amplitude | ↓ α1 & α2 clusters | ↓ Inhibition |
↓ Evoked IPSCs |
