Figure 1 | Scientific Reports

Figure 1

From: PDGFBB facilitates tumorigenesis and malignancy of lung adenocarcinoma associated with PI3K-AKT/MAPK signaling

Figure 1

The PDGFBB expression and the Kaplan–Meier analysis in LUAD. (A) The frequency of gene alteration in lung adenocarcinoma (n = 566). (B) The Kaplan–Meier analysis of the LUAD patients with high or low PDGFB expression (n = 566). (C) The mRNA level of PDGFA, B, C and D in BEAS-2B, A549 and SPCA1 cells (n = 3–4). (D, E) The PDGFBB protein level in the supernatant and the cell of BEAS-2B, A549 and SPCA1 cells (n = 3). (F, G) The expression and distribution of PDGFRα and PDGFRβ in BEAS-2B, A549 and SPCA1 cells (n = 13–20). The lower panel was an enlarged view of the cells indicated by the arrows in the upper panel. BEAS-2B: a normal human lung epithelial cell; A549 and SPCA1 cells: lung adenocarcinoma cells. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA (C, D, E, G).

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